Lactoluxin® – herbistha

LACTOLUXIN® 

Trade Name: LACTOLUXIN® 

INCI Name: Liponiosome encapsulating fenugreek extract

Application: For skincare products such as serum, lotion, cream, etc.

Recommended Dose : 0.1%-2% (Clinically tested at maximum dose 2%)

Country of Origin: Thailand

Certificated: ISO/IEC 17025

Technology encapsulation of Liponiosome encapsulating fenugreek extract

LACTOLUXIN®, LNF (Liponiosome encapsulating fenugreek extract) 

          LACTOLUXIN® was developed and characterized with liponiosomes. it can enhance the capability and control the release of nano-carriers. Furthermore, they are deformable to penetrate pores that are much smaller than the carrier’s size and have the capability to transport both water and fat-soluble agents.  This innovation was highly stable, not toxic to human fibroblast, and was able to enhance cell viability, collagen production, and inhibit MMP1, MMP9, IL-6, and IL-8 secretions compared to the extract in the co-cultured skin model. Hence, LACTOLUXIN® as innovative anti-aging agents have high potential for active ingredients in cosmeceutical products.

Technology encapsulation for LACTOLUXIN®, LNF (Liponiosome encapsulating fenugreek extract)

TEM image of LACTOLUXIN®, LNF (Liponiosome encapsulating fenugreek extract) staining with uranyless

LACTOLUXIN® (Liponiosome encapsulating fenugreek extract)

Skin Permeation

           Nanoencapsulation is a technique that has been used to improve stability, increase water solubility, enhance skin permeation and absorption, and slowly release active ingredients.

           There are many different types of nanoparticles, such as liposomes, niosomes, and liponiosomes. Liponiosomes are composed of phospholipid and non-ionic surfactants that enhance the capability and control the release of nano-carriers. The morphology of liponiosomes resembles that of liposomes. 

           However, liponiosomes are more flexible and adaptable and, importantly, function differently. The advantages of liponiosome carriers are that they are deformable to penetrate pores that are much smaller than the carrier’s size and have the capability to transport both water and fat-soluble agents. Hence, liponiosomes are promising carriers for delivering an active ingredient into the skin .

The releasing profile and skin penetration of formulated LACTOLUXIN®, LNF (Liponiosome encapsulating fenugreek extract)

Porcine skin permeabilization . The IMS image showed the cumulative amount of rutin(Blue color) permeated through porcine skin, which was treated with rutin standard, fenugreek extract, and LNF(Liponiosome encapsulating fenugreek extract) for 24 Hr. Rutin was detected at 609m/z.

In vitro releasing profiles of LACTOLUXIN® within 24 Hr using Franz diffusion cells. 

Anti-Aging: Collagen production

LACTOLUXIN®, LNF (Liponiosome encapsulating fenugreek extract)  activities on collagen content with fibroblast cell. LNF can significantly increase the collagen production within 7days(collagen content  up 10% ) and 14 days (collagen content  up 20% ).

Mechanisms of LACTOLUXIN®, LNF (Liponiosome encapsulating fenugreek extract)  on anti-aging activity

 LACTOLUXIN®, LNF (Liponiosome encapsulating fenugreek extract) were able to significantly reduce the secretions of MMP1(25%) and MMP9(10%) compared to control cells after UV irradiation.

Anti-Inflammatory

Levels of UV-induced IL-6 and IL-8 secretions after fenugreek extract and LNF treatments section.

The treatment of fenugreek extract exhibited considerably higher IL-6 and IL-8 inhibitions in comparison with rutin, whereas these inhibitory activities were similar to resveratrol-treated groups. Notably, the expressions of IL-6 and IL-8 in LNF-treated cells were significantly lower compared to fenugreek extract group after UV exposure.

These results indicated that LNF could potentially inhibit UV-mediated IL-6 and IL-8 production, and subsequently prevent photo-stimulated skin inflammation and skin aging. As a consequence, these results suggest that ethanolic extract of fenugreek and its Nano formulation could potentially be used as active ingredients for the prevention of aging.

   LACTOLUXIN®   Irritation test (Patch test)

LACTOLUXIN® Natural Farming, Since 2015

In order to offer the best products to customers.
Our Product is made from high-quality sources in Natural farming system

Products on the Market with LACTOLUXIN®

LNF (Liponiosome encapsulating fenugreek extract)

Clinically tested with HERBISTHA® Serum

Publication: Journal Pharmaceuticals, Switzerland

idea2Expert Team

CEO
Pinit K.

R&D team and Manufacturing
Nanotec,NSTDA, Thailand

 LACTOLUXIN®

LNF (Liponiosome encapsulating fenugreek extract) 

Idea2Expert Co., Ltd. is the Thailand’s leading manufacturer and distributor of natural product with innovation for cosmeceuticals. We believe in using only the finest herbs and technology to research and develop the innovative products.“LACTOLUXIN®” (Liponiosome encapsulating fenugreek extract) is one of our innovation with high quality active ingredients in cosmeceutical products.

Contact us:
IDEA2EXPERT CO., LTD.

99/209 Soi Chaengwattana 12, YAK 4-7-4-1, Thung-Song-Hong, Laksi, Bangkok 10210. THAILAND Tel:+66 2 1678611 , email: idea2expert@gmail.com